Selected Podium Presentations
Invited Speaker “New Strategies in Microsampling (and Analysis) – Volumetric Absorptive Microsampling”. 14th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Rotterdam, 14 Oct 2015.
Invited Speaker “Developments in blood & plasma microsampling and considerations for their practical deployment”. 21st International Reid Bioanalytical Forum, Guildford, 7-10 Sept 2015.
Invited Speaker “Microsampling for quantitative drug bioanalysis – latest developments”. Alternative Sampling Strategies, Ghent, Belgium, 18-19 Sep 2014.
Invited Speaker “Microsampling: bioanalytical considerations”. Eurotox, Edinburgh, 9th Sep 2014.
Invited Speaker “GSK’s approach to wet plasma capillary microsampling – new method development and validation challenges” 8th Workshop on Recent Issues in Bioanalysis, Los Angeles CA, USA, 11-13 Mar 2014.
Invited Speaker “Dried blood spots (DBS) New Challenges – Method Development” 8th Workshop on Recent Issues in Bioanalysis, Los Angeles CA, USA, 11-13 Mar 2014.
Speaker “Latest Developments in Microsampling for Regulated Quantitative Bioanalysis” European Bioanalysis Forum, Barcelona, Spain, 20 – 22 Nov 2013.
Invited Speaker “Pharmaceutical Companies Perspective on the Challenges and Changes in Developing Partnerships with CROs” Reid Bioanalytical Forum 2013, Guildford, UK, 9-12 Sep 2013.
Speaker “Recent Advances and Future Directions in the use of Dried Blood Spot (DBS) Samples for the Quantitative Bioanalysis of Drugs”, AAPS, New Orleans, USA, 15-18th Nov 2010.
Speaker “Direct Analysis of DBS Samples” DIA DBS Workshop, Washington DC, USA, 8th Dec 2009.
Speaker “Logistical aspects of DBS” DIA DBS Workshop, Washington DC, USA, 8th Dec 2009.
Speaker “The Use of Dried Blood Spot Samples for Quantitative Drug Bioanalysis - Implementation at GlaxoSmithKline and Future Directions” EBF Symposium, Barcelona, Spain, 1-4 Dec 2009.
Speaker “The Use of Dried Blood Spot Samples for the Quantitative Bioanalysis of Drugs in PreClinical & Clinical Studies” 10th Annual Land O’Lakes Bioanalytical Conference, WI, USA, 14-17 July 2009.
Dr. Neil Spooner has published over 50 peer reviewed manuscripts and has made more than 30 podium presentations at major international scientific meetings. The following lists some of the recent highlights.
Selected Peer Reviewed Manuscripts
Felgate C, Spooner N, Calloway R (2016) An investigation of the comparability of commercially sourced plasma and pharmaceutical study plasma, using total protein concentration. Bioanalysis 8, In Press.
Spooner N, Denniff P, Michielsen L, De Vries R, Ji Q.C, Arnold ME, Woods K, Woolf EJ, Xu Y, Boutet V, Zane P, Kushon S, Rudge JB (2015) A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated with blood hematocrit. Bioanalysis 7, 653-659.
Denniff P, Parry S, Dopson W, Spooner N (2015) Quantitative bioanalysis of paracetamol in rats using volumetric adsorptive microsampling (VAMS) J. Pharm. Biomed. Anal. 108, 61-69.
Chapman K, Burnett J, Corvaro M, Mitchell D, Robinson S, Sangster T, Sparrow S, Spooner N, Wilson A (2014) Reducing pre-clinical blood volumes for toxicokinetics: toxicologists, pathologists and bioanalysts unite. Bioanalysis 6, 2965-2968.
Denniff P, Spooner N (2014) Volumetric absorptive microsampling: A dried sample collection technique for quantitative bioanalysis. Anal. Chem. 86, 8489-8495.
White S, Hawthorne G, Dillen L, Spooner N, Woods K, Sangster T, Cobb Z, Timmerman P (2014) EBF: reflection on bioanalytical assay requirements used to support liquid microsampling. Bioanalysis, 6, 2581-2586.
Summerfield S, Evans C, Spooner N, Dunn J, Szapacs M, Yang E (2014) Integrating internal and external bioanalytical support to deliver a diversified pharmaceutical portfolio. Bioanalysis 6, 1311-1319.
Evans C, Spooner N (2014) Pharmaceutical perspectives of use of dried blood spots. Book Chapter in Dried Blood Spots: Applications and Techniques, Lee MS & Li W Eds pp153–159.
Lafreniere NM, Shih SCC, Abu-Rabie P, Jebrail MJ, Spooner N, Wheeler AR (2014) Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics. Bioanalysis 6, 307-318.
Hughes S, Byrne A, Barfield M, Spooner N, Summerfield S (2014) Preliminary investigation into the use of a real time PCR method for the quantification of an oligonucleotide in human plasma and the development of novel acceptance criteria. Bioanalysis 6, 127-136.
Lelong C, Wickremsinhe E, Filali-Ansary A, Spooner N (2013) Training and microsample collection. Book Chapter in Microsampling in Pharmaceutical Bioanalysis, Zane P & Emmons GT Eds., pp15–28.
Bowen CL, Licea-Perez H, Karlinsey MZ, Jurusik K, Pierre E, Siple J, Kenney J, Stokes A, Spooner N, Evans C (2013) A novel approach to capillary plasma microsampling for quantitative bioanalysis. Bioanalysis 5, 1131-1135.
Patel P, Mulla H, Kairamkonda V, Spooner N, Gade S, Della Pasqua O, Field DJ, Pandya HC (2012) Dried blood spots and sparse sampling: a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants. Br. J. Clin. Pharmacol. 75, 805-813.
Manicke NE, Abu-Rabie P, Spooner N, Ouyang Z, Cooks RG (2011) Quantitative analysis of therapeutic drugs in dried blood spot samples by paper spray mass spectrometry: an avenue to therapeutic drug monitoring. J. Am. Soc. Mass Spectrom. 22, 1501-1507.
Stokes AH, Moose TA, Parry SP, Barfield M, Lovatt CA, Dopson WJ, Melich D, Overvold CR, Gade SD, Spooner N (2011) Determination of drug concentrations using dried blood spots: investigation of blood sampling and collection techniques in Crl:CD(SD) rats. Lab. Animals 45, 109-113.
Pandya HC, Spooner N, Mulla H (2011) Dried blood spots, pharmacokinetic studies and better medicines for children. Bioanalysis 3, 779-786.
Denniff P, Spooner N (2010) The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanlysis of drugs. Bioanalysis 2, 1385-1395.
Abu-Rabie P, Spooner N (2009) Direct Quantitative Bioanalysis of Drugs in Dried Blood Spot Samples Using a Thin-Layer Chromatography Mass Spectrometer Interface. Anal. Chem. 81, 10275-10284.
Spooner N, Lad R, Barfield M (2009) Dried blood spots as a novel sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Anal. Chem. 81, 1557-1563.
Barfield M, Spooner N, Lad R, Parry S and Fowles S (2008) Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies. J. Chromatogr. B, 870, 32-37.