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Spooner Bioanalytical Solutions

Throughout my working life I have authored over 70 peer reviewed manuscripts. A selection of these are displayed below.

Ahmad S, Baker D, Murnane D, Spooner N, Gerhard U (2021) Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis. Bioanalysis 13(14), 1101-1111.

Sen A, Gillett M, Weaver L, Barfield M, Singh P, Lapierre F, Spooner N (2020) In vitro testing of the hemaPEN microsampling device for the quantification of acetaminophen in human blood. Bioanalysis 12(24), 1725-1737.

Abu Rabie P, Neupane B, Spooner N, Rudge J, Denniff P, Mulla H, Pandya H (2019) Validation of methods for determining pediatric midazolam using wet whole blood and volumetric absorptive microsampling. Bioanalysis 11(19), 1739-1754.

Spooner N, Anderson K, Siple J, Wickremsinhe E, Xu Y, Lee M (2019) Microsampling - Considerations for its use in pharmaceutical drug discovery and development. Bioanalysis 11(10), 1015-1038.

Patel SR, Bryan P, Spooner N, Timmerman P, Wickremsinhe E (2019) Microsampling for Quantitative Bioanalysis, an Industry Update: Output from an AAPS/EBF Survey. Bioanalysis 11(7), 619-628.

Spooner N, Olatunji A, Webbley K. (2018) Investigation of the Effect of Blood Hematocrit and Lipid Content on the Blood Volume Deposited by a Disposable Dried Blood Spot Collection Device. J. Pharm. Biomed. Anal. 149, 419-424.

Panchal T, Spooner N, Barfield M (2017) Ensuring the collection of high quality dried blood spot samples across multisite clinical studies. Bioanalysis 9(2), 209-213.

Summerfield S, Barfield M, Spooner N, White S (2016) From patient to tube:  The importance of physiologically relevant quantitative bioanalytical assays. Bioanalysis 8(24), 2595-2604.

Spooner N., Denniff P., Michielsen L., De Vries R., Ji Q.C., Arnold M.E., Woods K., Woolf E.J., Xu Y., Boutet V., Zane P., Kushon S., Rudge J.B. (2015) A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated with blood hematocrit. Bioanalysis 7(6), 653-659.

Denniff P., Parry S., Dopson W., Spooner N. (2015) Quantitative bioanalysis of paracetamol in rats using volumetric adsorptive microsampling (VAMS) J. Pharm. Biomed. Anal. 108, 61-69.

Lafreniere N.M., Mudrik J.M., Ng A.H.C., Seale B., Spooner N., Wheeler A.R. (2014) Attractive design:  An elution solvent optimisation platform for magnetic-bead-based fractionation using digital microfluidics and design of experiments. Anal. Chem. 87, 3902-3910.

Ahmad S., Tucker M., Spooner N., Murnane D., Gerhard U. (2014) Direct ionisation of solid phase microextraction fibres for quantitative drug bioanalysi: From peripheral circulation to mass spectrometry detection. Anal. Chem. 87, 754-759.

Chapman K., Burnett J., Corvaro M., Mitchell D., Robinson S., Sangster T., Sparrow S., Spooner N., Wilson A. (2014) Reducing pre-clinical blood volumes for toxicokinetics: toxicologists, pathologists and bioanalysts unite. Bioanalysis 6(22), 2965-2968.

Denniff P., Spooner N. (2014) Volumetric absorptive microsampling: A dried sample collection technique for quantitative bioanalysis. Anal. Chem. 86, 8489-8495.

Bowen C.L., Licea-Perez H., Karlinsey M.Z., Jurusik K., Pierre E., Siple J., Kenney J., Stokes A., Spooner N., Evans C. (2013) A novel approach to capillary plasma microsampling for quantitative bioanalysis.  Bioanalysis 5, 1131-1135.

Patel P., Mulla H., Kairamkonda V., Spooner N., Gade S., Della Pasqua O., Field D.J., Pandya H.C. (2012) Dried blood spots and sparse sampling: a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants. Br. J. Clin. Pharmacol. 75, 805-813.

Pandya H.C., Spooner N., Mulla H. (2011) Dried blood spots, pharmacokinetic studies and better medicines for children. Bioanalysis 3, 779-786.

Spooner N., Ramakrishnan Y., Barfield M., Dewit O., Miller S. (2010) Use of DBS sample collection to determine circulating drug concentrations in clinical trials: practicalities and considerations. Bioanalysis 2, 1515-1522.

Denniff P., Spooner N. (2010) The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanlysis of drugs. Bioanalysis 2, 1385-1395.

Spooner N., Lad R., Barfield M. (2009) Dried blood spots as a novel sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Anal. Chem. 81, 1557-1563.

Barfield M., Spooner N., Lad R., Parry S. and Fowles S. (2008) Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies. J. Chromatogr. B, 870, 32-37.

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